Impact of Pre administration of Rosuvastatin on the Myocardial Reperfusion and Vagus Nerve Function in Elderly Patients with STE-MI by Chronic Pre treatment of Statins Undergoing Primary PCI
Lu Qing
Ding Shifang
Chen Zhinan
Jiang Juquan
Gong Zhigang
Li Zhigang
Fu Wenbo
Abstract：Objective To compare the level of myocardial reperfusion and vagus nerve function with different previous therapy of rosu-vastatin in elderly patients suffered from ST segment elevation myocardial infarction (STEMI)with the chronic pre treatment of statins un-dergoing primary percutaneous coronary intervention (PCI).Methods One hundred and eighteen consecutive elderly patients suf-fered from STEMI first time undergoing primary PCI were enrol ed.According to the history with the chronic pre treatment of statins, they were randomly divided into the group with chronic pre treatment of statins (n=32),high dose group(n=45)and convention-al dose group(n=41).Creatine kinaseMB(CK MB),troponin T (TnT),hs CRP,interleukin 6 (IL 6)and lipids levels were fested before and after PCI.Myocardial reperfusion was evaluated during PCI.On 7 days and 40 days after PCI,the deceleration ce-pacity of rate(DC)and chemoreflex sensitivity (ChRS)were measured.The occurrence of major adverse cardiovascular events and adverse drug reactions were observed within 40 days after PCI.Results The levels of CK MB,TnT,hs CRP,IL 6 and,lipids and myocardial reperfusion in the group with chronic pre treatment of statins and high dose group were significantly better than those in the conventional dose group(P<0.05).After PCI,compared with the conventional dose group,the DC,percentages of low risk pa-tients and ChRS in the group with chronic pre treatment of statins and high dose group were significantly higher,and percentages of high risk patients were lower obviously(P<0.05).Compared with the conventional dose group,the incidence of angina pectoris post PCI,heart failure,severe ventricular arrhythmia and LVEF were significantly better in the other two groups (P<0.05).Conclu-sion Conventional dose pre treatment with rosuvastatin for elderly patients suffered from STEMI with the chronic pre treatment of statins Conld al eviate the ischemic myocardial reperfusion,protected myocardial,increase vagal activity,reduced the incidence of severe ventricular arrhythmia,and improve the recent clinical effects.
Keywords：ST segment elevation myocardial infarctionelderly patientsstatinmyocardial reperfusionvagus nerveprimary percu-taneous coronary intervention
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 2857-2863 )