The Iufluence of Furong Tongmai Capsule on the Expressions of PAI 1 and t PA in Thoracic Aorta Tissue of Diabetic Rats
Cui Ronggang
Tian Fengsheng
Su Yang
Bai Hailong
Bian Yun
Meng Xiaofeng
Abstract：Objective To observe the effects of Furong Tongmai capsule (FTC)on the expressions of plasminogen activator inhibitor 1 (PAI 1)and tissue plasminogen activator (t PA)in thoracic aorta tissue of diabetic rats,and explore its possible mechanism.Meth-ods Wistar rats were randomly chosen as blank control group and diabetes model group.The diabetic model rats were randomly di-vided into DM,FTC low dose group,FTC medium dose group,FTC high dose group.Aftet 8 weeks later,we observed the blood sug-ar and the expression levels of PAI 1,t PA with immunohistochemical technique.Results The blood sugar of diabetic rats was sig-nificantly higher than that in control group.The expression of PAI 1 in thoracic aortic was decreased in FTC medium dose group and FTC high dose group.The expression of t PA in thoracic aortic was increased in FTC medium dose group and FTC high dose group.Conclusion FTC could improve the expression of t PA,inhibit the over expression of PAI 1 in thoracic aorta tissues of diabetic rats.
Keywords：diabetic macroangiopathyFurong Tongmai capsulesplasminogen activator inhibitor 1tissue plasminogen activator
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2762-2766 )