The Influence of Icari n on the Expression of COX 2 in Rats with Alzheimer like Model
Zhen Jin
Wang Meiling
Zhu Runxiu
Xiao Mei
Fu Yongwang
Guo Jianxiong
Abstract：Objective To investigate the influence of icari n (ICA)on the expression of cyclooxygramse 2 (COX 2)in inflammational rat model hippocampus with Alzheimer’s disease(AD)induced by lipopolysaccharides(LPS). Methods Thirty six rats were al oca-ted into 4 groups:control group,model group,low dose ICA group and high dose ICA group.The rat models of AD were induced by being injected LPS into the lateral cerebral ventricle. After two weeks of intragastric administration,brain tissue of rats was removed. The expressions of COX 2 protein and mRNA in hippocampus of the rats were detected by immunohistochemistry(SP method)and SYBR GREEN fluorescence quantitative RT PCR. Results The expressions of COX 2 protein and mRNA in high dose ICA group were significantly lower than those in model group (P<0.01). Conclusion The high dose ICA can reduce the expression of COX 2 in inflammational rat model hippocampus of AD and can inhibit the inflammatory reaction of nerve cel s injury.
Keywords：Alzheimer’s diseaseicari ncyclooxygramse 2lipopolysaccharides
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2629-2630 )