Correlation between Serum GFAP Levels and Cognitive Impairment in Patients with Cerebral Infarction
Liu Yuming
Deng Yanhua
Xu Zhiqiang
Abstract：Objective To investigate the serum glial fibril ary acidic protein (GFAP)level in patients with cerebral infarction (CI),and to analyze its correlation with cognitive impairment. Methods One hundred and sixty two patients with CI were included in this study and their serum GFAP levels at 3 days,1 month,3 months after onset were measured,and analyzes its correlation with infarct size,myocardial infarction site and cognitive impairment after stroke. Results The serum GFAP level in large infarct size patients were significantly higher than other groups at 3 days and 1 month after onset (P<0.05). Patients whose infarction at cortical and subcortical infarction patients had a higher serum GFAP level at 3 days and 1 month after onset (P<0.05). The serum GFAP level in patients without cognitive impairment and with severe cognitive dysfunction had statistical significance at 3 days and 1 month after onset (P<0.05). There was a negative correlation of serum GFAP at 3 days and 1 month after onset and MMSE score (r=-0.731,P<0.05;r=-0.490,P<0.05). Conclusion The serum GFAP in patients with the onset of 3 days and 1 month of CI have relationship with infarct size,myocardial infarction site which influence patients cognitive impairment,but after the onset of 3 months the serum GFAP level and each index had no relationship.
Keywords：cerebral infarctionglial fibril ary acidic proteincognitive impairment
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2606-2608 )