The Infuence of Different Time Application of Tirofiban on the Immediate Targetangiography and Myocardial Injury in Patients with Acute ST segment Elevation Myocardial Infarction undergoing Percutaneous Coronary Intervention
Zou Hangbin
Huang He
Abstract：Objective To explore the effects of different time application of tirofiban on immediate targetangiography and myocardial injury in patients with acute ST segment elevation myocardial infarction (STEMI)undergoing percutaneous coronary intervention (PCI). Methods Two hundreds patients with STEMI undergoing PCI were selected in our hospital from February 2011 to May 2014, in accordance with the different time application of tirofiban were divided into three groups,in the resuscitation room of tirofiban in pa-tients with 95 cases as group A,the application of tirofiban therapy in patients with 56 cases as group B,without the use of tirofiban intracoronary injection of equal,at the same time to the 0.9% Sodium Chloride injection treatment in patients with 49 cases as the control group,the remaining lipid,anticoagulation therapy were the same. The immediate target of angiography was evaluated by thrombolysis in myocardial infarction (TIMI)blood flow and myocardial perfusion grading standards. The changes of biochemical markers of myocardial injury were observed before and after PCI. The major adverse cardiovascular events (MACE),bleeding com-plications and the incidence of thrombocytopenia were observed. Results There was no difference in the TIMI flow grade and PCI myocardial perfusion grade among three groups before PCI(P>0.05). After PCI,TIMI flow grades were unchanged in three groups (P>0.05). The myocardial perfusion grades in group A and group B were better than that in control group (P<0.05). There was no difference in the contents of CK MB and cTNT among three groups before PCI(P>0.05). After PCI,There was a difference in the contents of CK MB and cTNT among three groups(P<0.05). After fol ow up for 6 months,There was no difference in the oc-currence of bleeding,thrombocytopenia,MACE among three groups(P>0.05). Conclusion Early application of tirofiban in patients with STEMI undergoing emergency PCI can improve the immediate infarction related artery blood flow and myocardial perfusion,re-duce the degree of myocardial injury,complications,and adverse reactions could be tolerated.
Keywords：acute ST segment elevation myocardial infarctionpercutaneous coronary interventiontirofibantargetangiographycrea-tine kinase MB isoenzymecardiac troponin T
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2603-2606 )