Detection of Polymorphism of ABCA1 Gene 69C/T and Its Association with Blood Lipids Level and Coronary Heart Disease in Mongo-lian Population
Yuan Tuoya
Liu Xiaoyu
Wang Yuexi
Abstract：Objective To investigate whether ATP binding cassette transporter A1(ABCA1)gene 69C/T single nucleotide polymor-phisms variation was correlated with coronary heart disease(CHD)in Mongolian population of the Inner Mongolia region,and the as-sociation of this polymorphism with blood lipids. Methods The target fragments of ABCA1 gene was amplified and analyzed by poly-merase chain reaction(PCR) restriction fragments length polymorphism(RFLP)technique in 203 Mongolian patients with CHD and Mongolian control subjects without CHD. Results The frequency of TT genotype and T al ele of ABCA1 69C/T gene was al signifi-cantly higher in CHD patients than that in controls(P<0.05). TT genotype adds ratio was 2.698 (95% CI:1.408 to 5.170,P<0.05).It showed that TT genotype was risk factorsfor CHD accidents by relative risk analysis. There was no significant difference in the levels of high density lipoprotein cholesterol (HDL C),low density lipoprotein cholesterol (LDL C),cholesterol (TC),triglycerides (TG)among three genotype of 69C/T (TT,TC,CC)gene (P>0.05).Conclusion ABCA1 gene 69C/T and polymorphism is associ-ated with CHD risk in Mongolian population of the Inner Mongolia region.The TT genotype of the ABCA1 gene C69T polymorphism is associated with increased CHD risk.
Keywords：coronary heart diseaseATP binding cassette transporter A1polymorphismblood lipids
Publication Date：2016-01-01
Pages：4( 2597-2599,2600 )