Non O Blood Group Increased the Risk of Coronary Heart Disease and Myocardial Infarction Through Elevated High Sensitive C reactive Protein and Serum Lipid Levels
Yu Zhimin
Zhang Fangfang
Zheng Yafen
Zhang Lijuan
Wang Zhiquan
Abstract：Objective To investigate the association of non O blood group with coronary heart disease (CHD)and myocardial infarc-tion (MI)and possible mechanisms. Methods A total of 304 consecutive CHD patients,149 MI patients and 201 controls were en-rol ed. The ABO blood groups,high sensitive C reactive protein (hs CRP),serum lipid profiles and other biological variables were measured. Results Compared with control group,CHD group [OR=2.09,95% CI (1.32,3.29),P<0.01]and MI group[OR=2.09, 95% CI (1.32,3.29),P<0.01]had more proportions of non O blood group. The hs CRP,total cholesterol (TC),low density lipoprotein cholesterol (LDL C)and non high density lipoprotein cholesterol(NHDL C)were significantly higher while high density lipoprotein cholesterol (HDL C)were significantly lower in CHD and MI group than in control group(P<0.01). The hs CRP was significantly higher in MI group than in CHD group(P<0.01). Hs CRP,TC,LDL C,and NHDL C were significantly higher in non O blood group than in O blood goup(P<0.05). Multivariate logistic regression analysis showed that non O group,hs CRP,male gender,age were the independent risk factors for CHD. Conclusion Non O group can increase the risk of CHD and MI might through elevated the levels of hs CRP and serum cholesterol.
Keywords：ABO blood groupshigh sensitive C reactive proteinserum lipidcoronary heart diseasemyocardial infarction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2511-2514 )