Effects of Chaihu Shugan Power on the Levels of Monoamine Neurotransmitters in the Hippocampus and Hypothalamus in Rats with Liver- qi Stagnation Syndrome
Ma Yufeng
Wang Jialing
Xing Jia
Zhu Xiaochen
Yue Guangxin
Wang Yulai
Guo Rongjuan
He Lijuan
Abstract：Objective To study the effects of Chaihu Shugan powder (CSD) on the ethological changes and levels of monoamine neu-rotransmitters in the hippocampus and hypothalamus in rats with liver qi stagnation syndrome.Methods The rat model with liver qi stagnation syndrome was established by chronic restraint stress and keeping them alone.Each rat was reviewed by Open field test, Sucrose test and determined the levels of monoamine neurotransmitters in the hippocampus and hypothalamus by high performance liquid chromatography (HPLC).Results The ethological manifestation of model rats was changed obviously,and the levels of 5 hydroxytryptamine (5 HT), 5 hydroxyindoleacetic acid (5 HIAA),dopamine(DA) in the hippocampus and hypothalamus were de-creased,while the level of norepinephrine (NE) was increased.CSD could regulate its trends.Conclusion CSD can improve the model rat’s ethological manifestation and have therapeutic effects of liver qi stagnation syndrome.The mechanism may be adjust the levels of 5 HT,5 HIAA,NE,DA in rat brain with liver qi stagnation syndrome,in order to effectively play the role of anti liver qi stagna-tion.
Keywords：liver qi stagnation syndromeChaihu Shugan powermonoamine neurotransmitters5- hydroxytryptamine5 hydroxyin-doleacetic aciddopamine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2494-2497 )