Traditional Chinese Medicine in the Treatment of Heart Failure with Normal Ejection Fraction:A Systematic Review
Ping Wei
Zhao Zhiqiang
Hou Xinying
Wang Xianliang
Hou Yazhu
Mao Jingyuan
Abstract：Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)for heart failure with normal ejection fraction(HFNEF).Methods Electronic literature of CNKI,VIP,WanFang,China biological medical (CBM)literature,Pubmed,EM-Base,Cochrane Library were searched until October,2015.Randomized control ed trails (RCTs)compared combined TCM with west-ern medicine in patients with HFPEF or DHF were eligible for inclusion.The analysis was performed with the software of Rev Man 5.3. Quality was assessed by using the Cochrane risk of bias tool .Results Nine RCTs,total y 636 patients with HFNEF were identified.Com-pared with the control group,the distances of the 6 minute walk test (6MWT)were increased [MD=1.24,95% CI (0.98,1.51),P<0.001],the values of N terminal pro B type natriuretic peptide (NT proBNP)reduced [MD=-135.97,95% CI (-164.60,-107.33),P<0.001],the E value reduced [MD=10.36,95% CI (6.81,13.92),P<0.001),the A value improved [MD=-6.28, 95% CI (-10.82,-1.75),P=0.007],the E/A value reduced [MD=0.30,95% CI (0.23,0.38),P<0.001]in the combination group.The efficiency was improved [RR= 1.29,95% CI (1.15,1.44),P<0.001].The clinical y significant efficiency was improved [RR=1.61,95% CI (1.19,2.19),P=0.002].No obvious adverse reactions and hepatic and renal impairment was reported during these trails.Conclusion Compared with the western medicine treatment,additional TCM for HFNEF was safe and effective.It could increase the distance of the 6MWT,reduce the values of NT pro BNP,the value of E ,the value E/A and the A value,improve the clinical efficacy.
Keywords：heart failure with normal ejection fractiondiastolic heart failuretraditional Chinese medicinesystematic review
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 2465-2471 )