Effects of Compound Herba Houttuyniae on Myocardial Injury in db/db Mice
Fang Yun
Wang Haiying
Abstract：Objective To investigate the effects of different extracts from compound HerbaHouttuyniae on development of diabetic car-diomyopathy in db/db mice.Methods db/m mice were in the normal group,and db/db mice were divided into six groups according to their treatment ways randomly:model group,metformin hydrochloride group,water extract group,ethanol extract group,volatile oil group,and mixture group (mixture of above three extract)of compound herba houttuyniae (n=8 for each).The change of body weight and fasting blood glucose (FBG)of mice were detected. Fins,transforming growth factor beta 1 (TGF β1),fibronectin (FN),glucagon like peptide 1 (GLP 1)were measured by ELISA after treatment with 8 weeks.The structures of myocardial ultra-structure were observed under electron microscope.Results Compared with normal group,the serum level of TGF β1 ,FN in ethanol extract group,volatile oil group,and mixture group were decreased(P<0.05).The level of GLP 1 in treatment groups except met-formin hydrochloride group were increased(P<0.05).And the myocardial ultrastructure were improved especial y in mixture group. Conclusion The compound herba houttuynia can lessen the cardiac pathologicalchange,and the mechanism may related to the de-crease of the level of TGF β1 ,FN and the increase of GLP 1.
Keywords：diabetic cardiomyopathycompound herbahouttuyniatransforming growth factor beta 1fibronectinglucagon like peptide 1
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2362-2366 )