Study of VKORC1 and CYP2C9 Plymorphism on Dosage of Warfarin in Atrial Fibril ation Patients in Inner Mongolian Area
Jiang Haitao
Li Wenzhong
Wang Shulin
Yang Huazhi
Lei Jingshu
Wang Dongfang
Abstract：Objective To investigate the relationship between vitamin K oxide reductase complex subunit 1 (VKORC1) 1639 G/A and cytochrome P450 (CYP)2C9 genetic polymorphicmand warfarin dosage in inner Mongolian populations.Methods The patients with atrialfibril ationwere divided into two groups:Mongolian group (n=300,Mongolian populations)and compared group (n=300,Han populations).PCR RFLP were used to analysis the VKORC1 1639 G/A and CYP2C9 genetic polymorphism,and the international normalized ratio(INR)in every patients were recorded. The mean warfarin dosage was compared according to different VKORC1 genotypes.Resluts The frequencies of the VKORC1 1639 AA,AG,GG genotypes in the Mongolian patient group were 78%,18%and 4%,and 76.5%,19%,4.5% in compared group.The al eles frequencies of VKORC1 1639 A and G were 87% and 13% in the Mongolian patient group,and 86% and 14% in compared group(P=0.26).The maintenance doses of warfarin was (2.98±1.6 )mg/d in AA genotype group,(3.67± 1.8)mg/d in AG genotype group and (4.36± 2.0)mg/d in GG genotype,respectively.There were 276 pa-tients were CYP2C9* 1/* 1,24 patients were CYP2C9* 1/* 3 in the Mongolian patient,279 patients were CYP2C9* 1/* 1,21 pa-tients were CYP2C9* 1/* 3 in the compared group.There was a significantly different among different VKORC1 and CYP2C9 geno-types patients (P<0.05).The dosage in CYP2C9* 1/* 1 with VKORC1 AG patients were higher than the other groups,and the dos-age in CYP2C9* 1/* 1 with VKORC1 AA were higher than that in CYP2C9* 1/* 3 with VKORC1 AA groups.Conclusion There was no significant difference ingenotype distribution of VKORC1 1639 G/A and CYP2C9 between the Mongolian patients and the Chinese Han population patient,but the VKORC1 1639 AA,AG,GG and CYP2C9* 1/* 1 ,CYP2C9* 1/* 3 genotypes influent the warfarin dosage.
Keywords：warfarinvitamin K oxide reductase complex subunit 1cytochrome P450 2C9genetic polymorphismMongolian
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2340-2344 )