Influences of Component Comptibility Sini Decoction on Hypothyroidism Complicated with Hyperlipidemia and Cardiovascular Injury

Wang Yan; Pei Miaorong

doi:10.3969/j.issn.1672-1349.2016.19.009

Abstract：Objective To investigate the influences of component comptibility Sini decoction (CCSD)on hypothyroid complicated with hyperlipemia and cardiovascular injury.Methods The hypothyroidism model was established by 0.1% propylthiouracil (PTU)solution 10 mL/kg for 15 days.The hypothyroidism animal were randomly divided into model group,CCSD high,middle,low dose group and positive drugs group,at the same time the mice should give the 0.1% PTU for 4 weeks.At the end of the experiment,took the blood and kidney,separated the serum. Radioimmunoassay was used to determine the serum tri odothyronine (T3),thyroxine (T4). UV spectrophotometer was used to detected the total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL C), myocardium Na+ K+ ATP enzyme activity concentration.ELEASE method were used to measure the serum atrial natriuretic peptide (ANP),endothelin (ET).Results Compared with blank group,T3,T4 concentration were decreased while thyroid stimulating hor-mone (TSH)concentration was increased in model group (P<0.01).Compared with model group,TG,TC,LDL C levels were de-creased in CCSD high,middle dose group(P<0.05).Compared with blank group,TG,TC,LDL C levels were increased(P<0.05 or P<0.01).Compared with model group,T3,T4 concentration were increased while TSH concentration was decreased in CCSD high,middle dose group(P<0.05).The levels of ANP,ET and Na+ K+ ATP enzyme activity in model group and CCSD group(P<0.05 or P<0.01).Compared with model group,ANP level was increased in CCSD groups(P<0.01).ET level was increased in CCSD high dose group(P<0.05).Conclusion CCSD can al eviate hyperlipemia and cardiovascular injury in hypothyroidism model rats.