The Infcuence of Yiqi Huoxue Jiedu Formula on Early Adventitial Inflammation and Vascular Remodeling after Vascular Injury
Yang Ruixue
Zhao Mingjing
Lei Huan
Chang Hong
Zhao Yizhou
Wu Aiming
Yang Tao
Han Xiaowan
Wang Lei
Li Tong
Abstract：Objective This study aims to observe early adventitial inflammation and vascular remodeling after bal oon injury of vascu-lar intima and the effect of Yiqihuoxuejiedu Formula.Methods The model of left common carotid artery bal oon injury with rats was used,and model rats were randomly divided into model group,atorvastatin group,Xuefuzhuyu group and Yiqihuoxuejiedu group with sham group as the control. Seven days after dosing,the area and the thickness of the vascular wal were observeded by HE staining. The levels of monocyte chemoattractant protein1(MCP 1)and the macrophage marker CD68 were assessed by immunohistochemi-cal staining. Results Compared with sham group,the intima area increased(P<0.01),adventitia thickening grew(P<0.05)and the concentrations of CD68added significantly (P<0.05),but the lumen area and integrated optical density of MC 1 did not signifi-cantly change in the model group. Compared with model group,Yiqihuoxuejiedu Formula could obviously reduce the intimal area (P<0.05)and lower CD68 level remarkably(P<0.01). Compared with Xuefuzhuyu group,Yiqihuoxuejiedu Formula could reduce adven-titial thickness obviously. Conclusion The vessel wal mainly presents positive remodeling withadventitia thickening and inflammatory reaction in the early stage of common carotid artery bal oon injury. Yiqihuoxuejiedu Formula can improve vascular remodeling effec-tivelyby the reduction of macrophage infiltration and inhibition of adventitial inflammation.
Keywords：vascular remodelingbal oon injuryinflammationYiqihuoxuejiedu Formula
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 2230-2235 )