Correlation between Adrenal Cortical Function and Kidney Deficiency Syndrome in Autoimmune Thyroid Disease
Duan Sujing
Chen Jianfei
Tan Wei
liang Jie
Yan Yue Yan
Abstract：Objective To study the correlation between adrenal cortical function and kidney deficiency syndrome in patients with auto-immune thyroid disease (AITD).Methods Ninety patients with positive thyroglobulin antibody (TGAb)and thyroid oxidase antibody (TPOAb)were selected,and divided into normal thyroid function group (group A,n=30),hyperthyroidism group (group B,n=30), hypothyroidism group (group C,n=30).Thirty healthy individuals were as controls.The serum cortisol level was detected at 08:00, 16:00.The area under the concentration time curve (AUC)was calculated.ECG were determined.The traditional Chinese medicine (TCM)syndrome types were observed by the scale of kidney- yang deficiency syndrome and kidney yin deficiency syndrome.Re-sults Compared with the control group,TGAb and TPOAb increased significantly in group B and group C (P<0.05 or P<0.01). AITD patients with kidney- yang deficiency syndrome was 93.3% in group C,and there was no kidney yin deficiency syndrome.AI-TD patients with kidney- yin deficiency syndrome was 66.7% in group B,and there was no kidney- yang deficiency syndrome.Serum cortisol levels in group C were lower than that in group A and control group(P<0.05).Conclusion TGAb and TPOAb increase sig-nificantly in AITD patients with thyroid dysfunction.The low level of adrenal function is positively correlated with kidney- yang defi-ciency syndrome.Early determination of thyroid hormone level and its antibody and adrenal cortex function has important clinical sig-nificance for the early diagnosis of kidney deficiency syndrome and the prevention and treatment of cardiac and cerebral diseases.
Keywords：autoimmune thyroid diseasethyroid autoimmune antibodiesadrenal functionkidney deficiency syndrome
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2227-2229 )