Effect of Ulinastatin on Myocardial Ischemia Reperfusion Injury after Emergency Percutaneous Coronary Intervention
Lan Yunjing
Ning Lin
Zhou Yinpin
Hu Longjiang
Abstract：Objective To investigate the effects and its mechanism of ulinastatin on myocardial ischemia reperfusion injury after emer-gency percutaneous coronary intervention (PCI). Methods One hundred and twenty patients undergoing directed PCI were random-ly divided into observation group and control group,60 cases in each group. The control group were given routine emergency PCI treatment,the observation group were treated with ulinastatin 10 000 U/kg additional y. The levels of adiponectin (APN),tumor nec-rosis factor alpha (TNF α),myocardial ischemia and reperfusion injury rate,and the area of creatine kinase MB (CK MB)con-centration time curve in two groups were compared. Results The levels of TNF αin the observation group were significantly lower than those in the control group(t=4.298,t=5.190,P<0.01),but APN was significantly higher (t=2.725,t=3.802,P<0.01). The incidence of myocardial ischemia reperfusion injury in the observation group was significantly lower than that in the control group (χ2=5.763,P<0.01). The area under the CK MB concentration time curve was significantly lower than that in the control group (t=32.694,P<0.01). Conclusion Ulinastatin can inhibit the inflammatory excessive activation to prevent reperfusion injury in pa-tients with myocardial ischemia.
Keywords：acute myocardial infarctionemergency percutaneous coronary interventionulinastatinadiponectin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2147-2150 )