Effects of Yangxin 2 Decoction on the Levels of Serum TNF α,IL 10 and iNOS in Rats with Chronic Heart Failure
Liu Haihua
Li Shanghong
Pan Tao
Zhang Binxia
Abstract：Objective To study the effect of Yangxin 2 decoction (YXD 2)on the levels of tumor necrosis factor alpha (TNF α) and interleukin 10(IL 10)and induced nitric oxide synthase(iNOS)in rats with chronic heart failure(CHF).To explore the mecha-nism of YXD 2 for the treatment of CHF.Methods Forty five male Sprague Dawley (SD)rats were divided into normal group (Con group,n=6)and CHF group(n=39).The model group was injected hypodermic with ISO for 28 consecutive days .After the model is successful y established in CHF,the survival rats were randomly devided into three groups:model group (group M),Carve-dilol group (group C)and YXD 2 group(group Y).Group C and group Y were received gastric gavage of carvedilol and YXD 2,re-spectively.The Con group and group M were received gastric gavage of distil ed water.After 28 days of dosing,the levels of serum TNF αand IL 10 and iNOS were tested,Results Compared with the Con group,the levels of serum TNF αwere increased in group M(P<0.05),the levels of serum IL 10 were decreased in group M(P<0.05),and iNOS were increased in group M.Com-pared with group M,the levels of serum TNF αwere decreased,the levels of serum IL 10 were increased and iNOS were de-creasedin group C and group Y (P<0.05).Conclusion YXD 2 can reduce the concentration of serum TNF αand increase the concentration of serum IL 10,reduce the concentration of serum iNOS,and improve cardiac function.
Keywords：chronic heart failureYangxin 2 decoctiontumor necrosis factor alphainterleukin 10induced nitric oxide synthase
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1993-1995 )