Relationship between E670G Polymorphism of PCSK9 Gene and Susceptibility to Coronary Heart Disease of Uygur Population in Xin-jiang Uygur Autonomous Region
Shan Xuefeng
Liu Cheng
Sun Qingchao
Jin Xiaochuang
Ma Songfeng
Abstract：Objective To investigate the frequency distribution of proprotein convertase subtilisin/kexin 9 (PCSK9)gene E670G poly-morphism and their relationship with coronary heart disease (CHD)between of Uygur population in Xinjiang Uygur Autonomous Re-gion.Methods The E670G polymorphism was identified by polymerase chain reaction restriction fragment length polymorphism in 368 patients with CHD (including 176 Uygurs and 192 Han population)and 372 health controls (including 167 Uygurs healthy individ-uals and 205 Han healthy individuals),and some specimens were sequenced.Results The levels of total cholesterol (TC)and low density lipoprotein cholesterol (LDL C)in CHD group were significantly higher than that in control group,high density lipoprotein cholesterol (HDL C)level in CHD group was significantly lower than that in control group(P<0.05).There was no difference in the levels of HDL C and triglyceride (TG)between CHD group and control group genotypes.There was difference in the levels of TC, LDL C between CHD group and the control group AG genotype(P<0.05).TC levels and LDL C levels of CHD group AA genotype was significantly higher than that of control group AA genotype (P<0.05).The levels of TC and LDL C in CHD group AG genotype was significantly higher than that of control group AG genotype(P<0.05).CHD group ATG genotypes and G al ele frequency in the control group increased PCSK9 gene,AA genotype reduction,AA genotype differences AG genotype and G al ele was statistical y significant (P<0.05).Xinjiang Uygur AG genotype and G al ele were higher than the Han,Uygur AA genotypes and A al ele frequen-cies were lower than the Han nationality,the distribution of genotypes and al ele frequencies between the two groups was statistical y significant (P<0.05).AG genotype,G al ele frequencies in Xinjiang Uygur CHD group were higher,AA genotypes and A al ele fre-quencies in CHD group were lower than that in control group,the difference was statistical y significant (P<0.05).Conclusion AA and AG genotype are dominant in the E670G polymorphism loci of PCSK9 gene.E670G PCSK9 gene polymorphisms is associated with increased TC,LDL C levels in CHD patients.Xinjiang Uygur population and Han population E670G polymorphism differences af-fecting gene PCSK9 E670G polymorphism exists for the development of CHD Uighur,G al ele may be a risk factor in Uygur patients with CHD.
Keywords：coronary heart diseaseUygurpolymorphismproprotein convertase subtilisin/kexin 9 genetotal cholesterollow density lipoprotein cholesterolhigh density lipoprotein cholesteroltriglyceride
Publication Date：2016-01-01
Pages：6( 1953-1958 )