Research on Mechanisms of Nourishing Qi,Warming Yang Activating Blood and Clearing Phlegm Therapies on the Myocardial Ener-gy metabolism in Rats with Heart Failure
Chen Jihong
Li Xiufen
He Ying
Ran Yajun
Abstract：Objective To explore the mechanism of nourishing qi,warming yang,activating blood and clearing phlegm therapies on the myocardial energy metabolism in rats with heart failure. Methods The rat model with heart failure was established. The rats with heart failure were randomly divided into model group,Qihong granule (QHG)low dose group,QHG medium dose group,QHG high dose group and the trimetazidine group,determination of irrigation to 12 weeks after heart failure.Na+ K+ ATPase,Ca2+ ATPase were tested. Left ventricular end systolic dimension (LVESD),left ventricular end diastolic diameter (LVEDD),left ventricular short axis shortening rate (FS),left ventricular ejection fraction (LVEF)were measured. Results After 12 weeks of treatment,the levels of Na+ K+ ATPase,Ca2+ ATPase were significantly increased in model group,QHG group and the trimetazidine group compared with blank group(P<0.05). Compared with model group,the levels of Na+ K+ ATPase,Ca2+ ATPase were significantly in-creased in QHG group and the trimetazidine group (P<0.05). Compared with blank group,LVESD increased,LVEF decreased in model group,QHG group and the trimetazidine group(P<0.05). Compared with model group,LVEDD,LVESD decreased,LVEF in-creased in QHG medium dose group,QHG high dose group and the trimetazidine group(P<0.05). Conclusion QHG can improve the content of Na+ K+ ATPase,Ca2+ ATPase,reduce the LVEDD,LVESD,increase the LVEF,thus protecting cardiac muscle,im-prove the symptoms of heart failure in rats,improve heart function in rats with heart failure.
Keywords：heart failurenourishing qiwarming yangactivating blood and clearing phlegm therapiesQihong granuleNa+ K+ AT-PaseCa2+ ATPasecardiac function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1854-1856 )