The Influence of Qigui Jiannao Prescription on Plasma Cholinesterase Activity and Cognitive Ability in Patients with Alzheimer’s Dis-ease
Wang Yinlong
Shan Tieying
Shan Tieqiang
Wang Xuedan
Su Anying
Pan Xiulan
Yan Xiulan
Yan Yingjie
Liu Fulai
Abstract：Objective To analysis the effect and clinical significance of Qigui Jiannao prescription (QJP)on plasma acetyl cholinester-ase activity and cognitive ability in patients with Alzheimer’s diseas (AD). Methods Sixty patients with AD ware randomly divided into two groups:QJP group (n=30)treated with oral Qiguijiannao prescription,each time 100 grams,2 times a day,and western medicine treatment group(n=30)treated with oral Naofukang,each time 0.8 grams,2 times a day. Both groups were treated for 6 months,the plasma AChE activity was determined before and after treatment,and the degree of mental retardation was assessed with simple intel igence status scale. Results The AChE activity and the scores of simple mental state scale of the two groups after treatment were significantly increased than before treatment (P<0.05),and compared with the differences between the two groups, there was not statistical significance (P>0. 05),but Qiguijiannao prescription group was superior to western medicine treatment group.Conclusion QJP can improve the activity of plasma AChE in patients with AD,and can significantly improve the cognitive abili-ty.
Keywords：Alzheimer’s diseasQigui Jiannao prescriptionpiracetamacetyl cholinesterasecognitive abilitydementia
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1852-1853 )