Clinical Significance of Serum NDKA and UFDP in Acute Ischemic Stroke Patients with Phlegm heat Syndrome
Han Xiuxiu
Ma Bin
Jiang Ru
Wang Yayun
Abstract：Objective To identify the value of the two biological makers nucleoside diphosphate kinase A(NDKA),ubiquitin fusion deg-radation protein(UFDP)for the the diagnosis and evaluation prognosis in acute ischemic stroke patients with phlegm heat syn-drome.Methods Fifty patients with phlegm heat syndrome and 30 age and gender matched healthy subjects were included in the study. The serum NDKA,UFDP levels were measured by ELISA kits at within 3 days of onset,and NIHSS scores,phlegm heat syn-drome scores were measured at day 14,BI scores were measured at day 90 after the onset.Results There was a significant differ-ence in serum UFDP(P=0.004)between acute stroke patients within 3 days of onset and healthy controls.The ROC curve of UFDP for the diagnosis of phlegm heat syndrome of traditional Chinese medicine(TCM)in acute ischemic stroke was 0.608. There was a significantly positive correlation between the serum NDKA levels and NIHSS scores(r=0.360,P=0.010),a significantly negative correlation between it and BI scores (r= -0.297,P=0.045),but a significant correlation was not found between the NDKA levels and phlegm heat syndrome scores.Conclusion The serum UFDP concentration exhibit diagnostic value for the phlegm heat syn-drome of TCM in patients with acute ischemic stroke,and the serum NDKA concentration within 3 days of onset exhibit evaluation value for recent nerve function defect degree and long term function disability levels in acute ischemic stroke patients with phlegm heat syndrome.
Keywords：ischemic strokephlegm heat syndromebiomarkersnucleoside diphosphate kinase Aubiquitin fusion degradation pro-tein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1841-1843 )