The Protective Effects of Catalpol on the Islet Cel s in Rats with Type 2 Diabetes Mel itus
Abstract：Objective To study the protective effects of catalpol on the islet cel s in rats with type 2 diabetes mel itus(T2DM).Methods Eight week old male wistar rats were randomly divided into the blank group(n=10)and the experimental group(n=90).The rats in experimental group were fed with high fat and high sugar diet for 8 weeks,after intraperitoneal injection of streptozotocin (STZ,15 mg/kg),with fasting blood glucose more than 16.7 mmol/L as T2DM molded standard.Sixty diabetic rats were randomly di-vided into model group,metformin group,catalpol low,middle and high dose group.The rats in blank group and model group were fed with distil ed water 5 mL/(kg·d).The rats in metformin group was given metformin 90 mg/(kg·d),The rats in catalpol low,middle and high dose groups were fed catalpol 2.5 mg/(kg· d),5 mg/(kg· d),10 mg/(kg· d).After 12 weeks,the rats fasting glucose,fast-ing serum insulin were measured,and the morphology of islet cel s were observed by Hematoxylin and Eosin (HE)staining.Results Compared with the model group,the insulin secretion index increased significantly in each drug intervention group. HE staining showed that islet cel structure was relatively intac in metformin group,catalpol low,medium and high dose groups. Conclusion Catalpol can protect the islet cel s.
Keywords：type 2 diabetes mel ituscatalpolinsulinmetformin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1727-1729 )