Correlation between CYP2C19 Gene Polymorphism and Coronary Heart Disease in Yunnan Han Population
Zhang Liguo
Yu Zhuo
Abstract：Objective To investigate the correlation between gene polymorphism of cytochrome P450 (CYP)2C19 and coronary heart disease (CHD)in Yunnan Han population.Methods One hundred and twenty seven Yunnan Han population were randomly select-ed from September 2012 to December 2013.Using gene chip assay,the genotypes were detected in the selected blood sample with genotype CYP2C19 gene sequence of single nucleotide polymorphisms CYP2C19* 1,CYP2C19* 2,CYP2C19* 3 genotype.The gene polymorphisms were analyzed in CHD group (n=63)and control group(n=64).The correlation of gene polymorphism and CHD were analyzed.Results Logistic regression analysis showed that in addition to age,sex,hypertension,diabetes,hypercholes-terolemia and other traditional risk factors,CYP2C19* 1/* 2 gene mutation significantly increased risk of CHD[OR=5.24,95% CI (2.00 to 13.72)],CYP2C19* 1/ * 3 gene mutation was also significantly increased the risk [OR= 4.54,95% CI (0.55 to 37.08)]. CYP2C19 gene polymorphism was an important risk factor for coronary heart disease in Yunnan Han population. Conclusion CYP2C19 gene polymorphism may increase the risk of coronary heart disease in Yunnan Han population.
Keywords：coronary heart diseasecytochrome P450 (CYP)2C19gene polymorphismYunnan Han population
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1597-1600 )