Clinical Observation on Shiyiwei Yixintang Particles in the Treatment of Chronic Heart Failure with Qi and Yin Deficiency and Blood Stasis Syndrome
Guo Ning
Zhang Shenggao
Ni Zhijun
Qian Hongyan
Tan Qiubo
Abstract：Objective To observe the clinical efficacy of Shiyiwei Yixintang particles(SYP)in the treatment of chronic heart failure (CHF)and its effects on the levels of plasma N terminal pro brain natriuretic peptide (NT proBNP),homocysteine (Hcy)and left ventricular ejection fraction (LVEF)in patients with CHF. Methods Sixty eight patients with CHF were randomly divided into two groups:control group (n=34)treated with routine western treatment,and treatment group(n=34)treated with SYP in the ba-sis of western routine treatment for four weeks.The LVEF as wel as the levels of plasma NT proBNP and Hcy were observed.The TCM integral of quantized symptom and signs were recorded before and after the treatment.Results After treatment,the level of plasma NT proBNP decreased significantly in two groups(P<0.05),which was lower in treatment group than that in control group (P<0.05).The levels of Hcy significantly decreased in two groups(P<0.05),but there was no significant difference between two groups(P>0.05).The LVEF were increased after treatment in two groups (P<0.05),which was higher in treatment group than that in control group (P<0.05).The TCM integral of quantized symptom and signs were improved in two groups after treatment(P<0.05), which was better in treatment group than that in control group(P<0.05).The total efficiency of treatment group was higher than that of control group (P<0.05).Conclusion SYP can decrease the levels of plasma NT proBNP and Hcy,improve the TCM integral of quantized symptom and signs,increase the LVEF,and improve the cardiac function in patients with CHF.
Keywords：chronic heart failureShiyiwei Yixintang particlesN terminal pro brain natriuretic peptidehomocysteineleft ventricular ejection fraction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1579-1581 )