Correlation between Vascular Endothelial Dysfunction and TCM Syndromes in Patients with Coronary Heart Disease and Heart Fail-ure after Myocardial Infarction
Li Lin
Wang Yan
Su Lin
Huang Li
Abstract：Objective To analyse the correlation between vascular endothelial dysfunction and traditional Chinese medicine(TCM) syndrome types in patients with coronary heart disease (CHD)and in which there were heart failure after myocardial infarction by clinical investigation.Methods We recruited 80 patients with CHD(heart function Ⅰ level),63 patients with heart failure after myo-cardial infarction (heart function Ⅱ to Ⅳ level).The age,sex,heart rate,blood pressure,vascular endothelial dependent diastolic function (FMD),homocysteine (tHcy),blood lipid,glycated hemoglobin (HbA1c),superoxide dismutase (SOD)and TCM syndrome types were analyzed by SPSS 20.0 statistical software.The vascular endothelial dysfunction was compared between two groups.Results Compared with patients with CHD(heart functionⅠ level),FMD value decreased obviously in heart failure after myocardial infarction (heart function Ⅱ to Ⅳ level)patients,and there was significant statistical significance (P<0.05).With the cardiac insufficiency, FMD value had further downward trend.FMD value was positively correlated with SOD,HDL C,and negatively correlated with age, LDL C,tHcy,HbA1c.Comparison of TCM syndrome type distribution found in coronary heart disease group,phlegm and blood stasis transresistancetype FMD value decreased significantly (P<0.05).In patients with heart failure after myocardial infarction,FMD value significantly decreased in patients with qi deficiency and blood stasis syndrome type(P<0.05).Conclusion The extent of the dam-age of vascular endothelial function in patients with heart failure after myocardial infarction (heart functionⅡ toⅣ level)is the most serious,and aggravates vascular endothelial dysfunction with cardiac insufficiency further.The study find that the endothelial function degree is correlated with risk factors of CHD and,for oxidative stress,age,blood lipids,homocysteine,blood glucose level and so on. TCM syndrome type distribution study shows that the endothelial dysfunction is heavier in patients with CHD and phlegm and blood stasis transresistance type.In patients with heart failure after myocardial infarction,the endothelial dysfunction with qi deficiency and blood stasis syndrome type is more serious.
Keywords：coronary heart diseaseheart failuremyocardial infarctionvascular endothelial functiontraditional Chinese medicine syn-drome types
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1569-1572 )