The Influence of Telmisartan on Adipocyte Size in Visceral Adipose of Sprague Dawley Rats with Insulin Resistance
Wu Gang
Rong Xinren
Wang Zhiping
Zhang Ruihu
Wang Yan
Abstract：Objective To observe the effect of telmisartan on the adipocyte size in epididymal fat tissue of Sprague Dawley(SD)rats with insulin resistance induced by a long term high sugar and fat diet(HSHFD),and to discuss the possible machanism of effect on degree of insulin resistance induced by telmisartan. Methods The male SD rats were randomly divided into three groups:the normal diet group(NC,n=10),the HSHF group (HSHF,n=6)and the HSHF+ Tel group (Tel,n=10).The rats were fed a HSHFD for 24 weeks in model groups,then the rats were intervened by telmisartan for 12 weeks in Tel group,the rats were fed as before for 12 weeks in NC group and HSHF group.Final y,in three groups,body weight (BW),fasting blood glucose(FPG),fasting serum insulin (FINS)and serum triglyceride (TG)were examined.Insulin resistance index was calculated.Meanwhile,the left epididymal adipose tissues were col ected from each rat and routinely stained using hematoxylin and eosin,the adipocyte size were observe with optical microscope.Results Compared with the NC group,BW,FPG,FINS,TG,HOMA IR in the HSHF group was significantly higher(P<0.05).Compared with the HSHF group,BW,FINS,TG,HOMA IR were significantly lower in the Tel group(P<0.05).FPG tended to be lower in Tel group,although the differences were not statistical y significant(P>0.05).The adipocyte size was almost same and smal in NC group.On the contrary,the adipocyte size was quite different and large in HSHF group.Compared with HSHF group,the adipocyte size was decreased in Tel group.Conclusion Telmisartan can prevent body weight gain and improve serum lipid metabo-lism and insulin resistance in rats fed with a long term HSHFD.Telmisartan can reduce the adipocyte size and fat content in epididy-mal fat tissue of rats fed with a long term HSHFD,possibly resulting in the improvement on insulin resistance.
Keywords：insulin resistancetelmisartanhigh sugar and fat dietadipocyte
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1224-1226 )