Observation on Curative Effect of High Dose Fluvastatin for Preventing Postoperative Contrast induced Nephropathy in Digital Subtraction Angiography
Fu Maolin
Dai Weizheng
Xiao Xueling
Ye Ying’an
He Wenqin
Abstract：Objective To investigate the effect of Effectiveness and safety of high dose fluvastatin for preventing postoperative con-trast induced nephropathy(CIN)in digital subtraction angiography (DSA).Methods One hundred and twenty DSA patients from A-pril 2012 to August 2014 were divided into 3 groups:control group(n=35),convention group(n=40)administered by 40 mg fluvas-tatin sodium capsule at each night of three days before DSA test,strength group(n=45)administered by 80 mg fluvastatin sodium capsule at each night of three days before DSA test.The preoperative and postoperative renal function,liver function and morbidity of CIN were observed.Results Compared with pre operation,postoperative Scr,Bun and Ccr in control group had significant differ-ences(P<0.05).There was significant difference in preoperative and postoperative Scr,Bun and Ccr between strength group and control group or convention group(P<0.05).The morbidity of CIN was 28.6% in control group,10.0% in conventional,0.0% in strength group,respectively(P<0.05).Conclusion High dose fluvastatin was relatively safe and effective to prevent postoperative CIN in DSA.
Keywords：contrast induced nephropathyfluvastatinpreventiondigital subtraction angiographyhigh dose
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1155-1158 )