Danhong Injection Improves Promotes Angiogenesis in Diabetic Mice with Lower Limb Ischemia
Zhang Zhengyan
Wang Peng
Wu Feng
Wu Zonggui
Abstract：Objective To investigate effect and mechanism of Danhong injection (DHI)on angiogenesis in the diabetic hind limb is-chemia mouse model.Methods Thirty diabetic hind limb ischemic model mice and ten normal mice,established by intraperitoneal (i.p.)injection of streptozotocin (STZ)or PBS and ligation/excision of femoral artery,then,twenty diabetic hind limb ischemic model mice of al were evenly randomized to saline (control)and DHI i.p.injection (2μL/g weight for 7days)groups.Limb perfusion recovery and femoral vessel regeneration and lower limb vascular endothelial growth factor (VEGF)expression were evaluated during inter-vention and after euthanasia,respectively. Results DHI i. p. increased ischemic limb perfusion and promoted col ateral circulation generation without decreasing blood glucose level.Increased local VEGF expression contributed to beneficial effects of DH injection. (n=10,P<0.05).Conclusion The activation of local VEGF signal pathway might participate in pro angiogenesis effects of DHI injection in diabetic hind limb ischemia model mice,suggesting a potential therapy for diabetic patients with critical limb ischemia.
Keywords：Danhong injectiondiabetic hind limb ischemiaangiogenesismicevascular endothelial growth factor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1078-1082 )