Relationship between Adiponectin and Insulin Resistance in Patients with Phlegm and Blood Stasis Type of Metabolic Syndrome Combined with Coronary Heart Disease
Lu Xiaoyan
Gao Yonghong
Li Geng
Sun Yikun
Xiao Yujuan
Abstract：Objective To investigate the relationship between the levels of adiponectin and insulin resistance (IR)in patients with phlegm and blood stasis type of metabolic syndrome (MS)combined with coronary heart disease (CHD).Methods Levels of serum adiponectin and insulin were measured by enzyme linked immunosorbent assay (ELISA)in phlegm and blood stasis type of 16 MS patients,17 MS+CHD patients,and 14 healthy controls.Other information on the conventional clinical features of MS,such as waist circumference and fasting blood levels of glucose and fat,was col ected,and homeostatic model assessment (HOMA) IR values were calculated.At the same time,coronary angiography data were col ected,and Gensini scores were calculated in CHD patients. Statistical analyses,such as Pearson correlation and regression analysis,were used in this study. Results There were significant differences in adiponectin among healthy controls (28.40μg/mL± 26.19μg/mL),patients with MS (15.47μg/mL± 8.06μg/mL),and patients with MS+CHD (12.75μg/mL± 3.74μg/mL).There were significant differences in HOMA IR among healthy controls (1.02± 0.152),patients with MS (1.75± 0.98),and patients with MS+CHD (1.60± 0.89).Pearson correlation analyses suggested that adi-ponectin was associated with gender;the level in women was less than in men.Furthermore,adiponectin was negatively correlated with hypertension.HOMA IR was positively correlated with diabetes,hypertension,and HS CRP.Logistic regression analysis indica-ted a statistical y significant relationship between adiponectin and gender,hypertension and HDL c,and Gensini score and adipone-ctin. Conclusion The levels of adiponectin were clearly decreased in patients with phlegm and blood stasis type of MS and lower in patients with MS+CHD,which were significantly correlated with the degree of coronary artery stenosis.This indicated that IR existed in both MS and CHD,and IR caused by the reduction of adiponectin might promote the progress of atherosclerosis,which contributes to the development of CHD from MS.Adiponectin levels could reflect the severity of IR disease and CHD,which had certain disease diagnosis and prediction value.
Keywords：metabolic syndromecoronary heart diseasephlegm and blood stasisadiponectininsulin resistance
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1057-1060 )