The Influence of Polygonum on Learning and Memory Function in Rats with Vascular Cognitive Impairment
Wang Zhouyi
Xia Guangming
Zhou Gang
Xiao Zhanchi
Huang Huxiang
Chen Haote
Li Gang
Abstract：Objective To investigate the impact of polygonum on learning and memory function in rats with vascular cognitive impair-ment(VCI).Methods Forty eight VCI model rats were randomly divided into four groups,namely polygonum high dose group,mid-dle dose group,low dose group,VCI model groups.Another 12 sham operated rats served as normal controls.After a successful modeling by gavage to rats is fed,fed a liquid temperature of 20℃,polygonum each treatment group were given different groups ac-cording to different concentrations of Polygonum solution mice in the model group,sham group were normal saline irrigation stomach, a total of 28 days.After 28 days the rats began to Morris water maze learning and memory ability behavioral tests,behavioral tests af-ter the end of the line expression of Bcl 2 immunohistochemistry,Bax positive cel s.Results Compared with the model group,es-cape latency was significantly shorter in polygonum middle dose group,high dose group(P<0.05 or P<0.01).The time of crossing the target quadrant was prolonged,the number of across the platform increased significantly(P<0.05 or P<0.01).After 28 days of modeling,the expressions of hippocampus Bcl 2 and Bax protein in each group was significantly higher than that in sham group. Compared with the model group,the magnitude of the increase Bcl 2 protein expression was significantly greater than the Bax pro-tein in polygonum middle dose group,high dose group(P<0.05 or P<0.01).Conclusion Polygonum can inhibit apoptosis by regu-lating the Bcl 2,Bax protein expression,and improve the learning and cognitive ability in rats with VCI.
Keywords：vascular dementiapolygonumlearning and memory functionBcl 2Bax
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 960-962 )