Risk Factors of Thrombocytopenia Associated with Tirofiban:an Analysis of 39 Cases
Wang Qiguo
Ge Zhenrong
Li Lan
Jiang Subin
Abstract：Objective To explore the incidence and risk factors of thrombocytopenia induced by tirofiban and to provide information in clinical practice.Methods The patients diagnosed as non ST elevation acute coronary syndrome(ACS)and treated with tirofiban were enrol ed in the study from May 2008 to July 2015.The data of general information,chronic disease,routine blood test,lipid,renal function were col ected and analysis.The incidence and risk factors of thrombocytopenia were assessment and analysis.Results Tirofiban associated thrombocytopenia was identified in 39 cases,the total rate was 4.16%.With mild,moderate and severe thrombo-cytopenia patients with 28 cases,8 cases and 3 cases respectively,the incidence was 2.99%,0.85% and 0.32% respectively.Com-pared with no thrombocytopenia patients,hypersensitive C reactive protein,platelet counts before prescription,left ventricular ejec-tion fraction (LVEF)were selected as risk factors of thrombocytopenia associated with tirofiban (P<0.05).Conclusion It is a rela-tively common complication of thrombocytopenia induced by tirofiban,and in most cases mainly with mild to moderate thrombocy-topenia.The age,heart function and basic level of platelet should be considerable in order to reduce the thrombocytopenia during the prescription of tirofiban.
Keywords：thrombocytopeniatirofibanrisk factorshypersensitive C reactive proteinleft ventricular ejection fraction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 949-951 )