The Influence of Resveratrol on the Myocardial Oxidation Related Genes in Rat Models with Heart Failure
Chen Jue
Yu Yue
Gao Xiang
Jiang Fengrong
Abstract：Objective To observe the effect of resveratrol(RES)on the myocardial oxidation related genes in rat models with heart failure(HF).Methods Sprague Dawley (SD)rat models with HF were established by partial y banding abdominal aortic artery.The cardiac fibrosis was evaluated by heart weight index(HWI).The expression of superoxide dismutase (SOD 1),heme oxygenase (HO 1),glutathione peroxidase (GPX)were measured by real time polymerase chain reaction (RT PCR).SOD was detected by immu-nohistochemistry.Results Compared with model group,HWI was significantly increased in RES group,especial y RES high dose group.The expression levels of SOD1,GPx,HO 1 were decreased in model group(P<0.01 or P<0.05).The expression levels of SOD1,GPx,HO 1 were increased in RES group(P<0.05),especial y SOD.The activity of SOD in RES high dose group was high-er than that in sham operation group.Conclusion RES can improve the expression of the myocardial oxidation related genes in rats with heart failure.
Keywords：heart failureresveratroloxidative stressratSuperoxide dismutaseheme oxygenaseglutathione peroxidase
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 704-706 )