The Influence of Total Panax Notoginseng Saponins on Vascular Endothelium Function and Nuclear Factor kappa B Expression in Patients with Atherosclerosis and Hyperlipidemia
Jiang Xiaoping
Zeng Fanpeng
Liu Shouming
Lin Xiaoyuan
Feng Sulian
Shen Zuhong
Abstract：Objective To study the effect of total panax notoginseng saponins (tPNS)on vascular endothelium function and nuclear factor kappa B(NF κB)in patients with atherosclerosis and hyperlipidemia.Methods Seventy one patients were randomly divid-ed into tPNS group and atorvastatin group.Before and after medication,the levels of serum NF κB,intracel ular adhesion molecule 1 (ICAM 1),nitric oxide (NO),prostacyclin (PGI2),superoxide dismutase (SOD),glutathione (GSH),carotid intima media thickness(CIMT)and atherosclerotic plaque were measured.Results After medication,the levels of serum NF κB,ICAM 1,and the scores of CIMT and atherosclerotic plaque were decreased while the levels of serum SOD and GSH were increased(P<0.05). Conclusion tPNS had protective effect on vascular endothelium function in patients with atherosclerosis and hyperlipidemia. This effect was related with downregulation of NF κB,ICAM 1 level and increase of NO,PGI2,SOD,GSH expression in patients with atherosclerosis and hyperlipidemia.
Keywords：atherosclerosistotal panax notoginseng saponinsnuclear factor kappa Bhyperlipidemiavascnlar endothelium
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 682-685 )