Effects of Jiedu Huoxue Prescription on Inflammation and Oxidative Stress in Patients with Acute Coronary Syndrome
Chen Liping
Chen Yan
Zhang Qiang
Zhao Shuxian
Su Zhenjie
Abstract：Objective To investigate the efficacy and mechanism of Jiedu Huoxue prescription(JHP)for treatment of acute coronary syndrome (ACS).Methods Eighty four patients with ACS were randomly divided into two groups:control group(n=42)treated with routine treatment,and treatment group(n=42)treated with JHP and routine treatment for 8 weeks.The levels of apolipoprotein B/apolipoprotein A Ⅰ (ApoB /ApoA Ⅰ),high sensitivity C reactive protein (hs CRP),interleukin 6 (IL 6),interleukin 8 (IL 8),myeloperoxidase (MPO),malondialdehyde (MDA),superoxide dismutase (SOD)were detected before treatment and after four weeks,eight weeks of treatment.Results After 8 weeks of treatment,the level of ApoB/ApoA Ⅰ in treatment group was lower than that in control group(P<0.05).After treatment,the levels of inflammatory cytokines and oxidative stress products were de-creased in two groups(P<0.05).After 8 weeks of treatment,the levels of hs CRP,IL 6,IL 8 in treatment group was lower than that in control group(P<0.05).After 4 weeks and 8 weeks of treatment,the levels of MPO and MDA in treatment group was lower than that in control group while SOD activity in treatment group was higher than that in control group(P<0.05 or P<0.01).Conclu-sion JHP can down regulate lipids,relieve inflammation and oxidative stress,improve prognosis in patients with ACS.
Keywords：acute coronary syndromeJiedu Huoxue prescriptioninflammationoxidative stressinterleukin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 576-579 )