Effects of Expel ing Wind to Eliminate Phlegm Methed on the Expression of Beclin 1 and LC3 in ApoE Gene Knockout Rats with Ath-erosclerosis Unstable Plaque
Ni Xiaoou
Gong Lihong
Zhang Shi
Bai Guangbiao
Abstract：Objective To observe the effect of Wenban decoction(WBD)with the function of expel ing wind to eliminate phiegm beclin 1 and LC3 in ApoE gene knockout rats with atherosclerosis(AS)on unstable plaque.Methods Six to eight weeks old ApoE gene de-ficient rats were selected to establish AS unstable plaque modle,and then they were given low dose,medium dose,high dose WBD and western medicine for a month.At the same time,the modle group was fed by normal saline for one month.Then aortic tis-sue was under optical microscope pathology after Hematoxylin and Eosin (HE)staining.And then levels of beclin 1 and LC3 were detected by western blot technique.Results Beclin 1 expression levels in aortic tissue of rats in middle dose WBD group,high dose WBD group and western medicine group was significantly higher than those in control group,the differences were statistical y significant(P<0.01).LC3 expression levels in aortic tissue of rats in treatment groups was significantly higher than those in control group,the differences were statistical y significant (P<0.01).Conclusion WBD with the function of expel ing wind to eliminate phiegm can influence the expression stability of atherosclerotic plaque by regulating beclin1 and LC3 protein.
Keywords：atherosclerosisexpel ing wind to eliminate phiegm treatmentWenban decoctionApoE grne knockout ratsunstable plaqueautophagybeclin 1LC3
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 488-491 )