Effects of Moxibustion with Seed sided Moxa Cone on Blood Pressure and the Expression of mTOR Protein in Spontaneously Hy-pertensive Rats
Guan Yuanyuan
Zhan Hongru
Zhang Haorang
Gu Yihuang
Abstract：Objective To observe the effects of moxibustion with seed sided moxa cone on blood pressure in spontaneously hyper-tensive rats(SHR)and the expression of mammalian target of rapamycin(mTOR)protein,so as to make preliminary discussion on its anti hypertensive mechanism.Methods Twenty SHR (12 weeks)were randomly divided into model group,and moxibustion group, 10 cases in each one.Another 10 Sprague Dawley(SD)rats (12 weeks)were set as normal group.Another 10 SD rats of 12 weeks with normal hypertension were regard as control group.The blood pressure of al rats were measured and recorded before the experi-ment.Rats in al group received identical feeding environment.Rats in model group and normal group did not received moxibustion. Rats in the moxibustion group received moxibustion with seed sized moxa cone at Zusanli Point and Quchi Point at the same time, 5 cones at each acupoint,once a day for 28 days.After the final moxibustion,blood pressure of al rats were measured and recorded again.Western blotting method was used to measure the levels of the expression of mTOR protein in cardiac muscle tissue.Results At 12 weeks,the blood pressure in model group and moxibustion group were higher than that in normal group(P<0.01),and there was no difference between model group and moxibustion group(P>0.05).After 16 weeks,the level of blood pressure were de-creased in moxibustion group,which was lower than that in model group(P<0.01).The expression of mTOR protein was obviously increased in moxibustion group,which was higher than that in model group and normal group(P<0.01).Conclusion Moxibustion with seed sided moxa cone may reduce the blood pressure in spontaneously hypertensive rats by regulate the expression of mTOR protein.
Keywords：hypertensionmoxibustion with seed sided moxa conemTOR proteinZusanli PointQuchi Point
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 361-363 )