Effect of Xinfukang Pil on Myocardial Hypertrophy by Pressure Overload in Rats
Chen Zuo
Liang Yong
Li Yanling
Gao Kejian
Abstract：Objective To explore effect of Xinfukang pil (XFKP)on pressure overload induced myocardial hypertrophy and echocar-diography in rats.Methods The experiment adopts the method of narrowing and contraction the aorta in adult and health Wistar rats,hence establishing the model of animals with myocardial hypertrophy and ventricular remodeling.Four weeks after coarctation of abdominal aorta,the Wistar rats were randomly divided into sham surgery(S group),model group(M group),enalapril group(E group),XFKP low dose group(L group),XFKP high dose group(H group).After 8,12 weeks,echocardiographic evaluation of cardiac function and cardiac hypertrophy index were observed.Results After eight weeks,rats in M group appear pressure overload media-ted concentric hypertrophy,twelve weeks later,rats in M group appear decompensated cardiac function.But these Pathological chan-ges can be inhibited in group E and H.The cardiac hypertrophy index was reduced significately(P<0.01).Conclusion XFKP could improve echocardiographic index and to reduce myocardial hypertrophy,and have a certain dose effect relationship.
Keywords：myocardial hypertrophyXinfukang pilpressure overloadabdominal aortic coarctationventricular remodeling
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 358-360 )