Effects of Tongbi Shuxin Granule on hs CRP,NT proBNP,Heart Rate Variability in Patients with Acute Coronary Syndrome Ac-companied by Anxiety and Depression
Liu Sanyun
Wang Jianming
Zhu Zhiyang
Qu Zhengyan
Shuai Zhongtai
Abstract：Objective To observe the effects of Tongbi Shuxin granule(TSG)on high sensitivity C reactive protein(hs CRP),N terminal pro B type natriuretic peptide (NT pro BNP),heart rate variability(HRV)in patients with acute coronary syndrome(ACS) accompanied by anxiety and depression.Methods Ninety patients with ACS accompanied by anxiety and depression were randomly divided into two groups according to the random number table method:The control group(n=45)treated with routine treatment plus emotional intervention,and the treatment group(n=45)treated with routine treatment,emotional intervention plus TSG for 12 weeks. The scores of Hamilton Anxiety Scale(HAMA)and the Hamilton Depression Scale(HAMD)were evaluated at admission,4th week, 12th week.The levels of hs CRP,NT proBNP and HRV were measured at admission and 12th week.Results After treatment,the scores of HAMA and HAMD were decreased,which were lower than that in control group(P<0.05).The scores of HAMA and HAMD were decreased,which were lower than that in control group(P<0.05).The levels of hs CRP and NT proBNP were decreased at 12th week,which were lower than that in control group(P<0.05).After treatment,RMSSD,PNN 50% and HF increased while LF and LF/HF decreased,which were better than that in control group(P<0.05).Conclusion TSG can reduce the scores of HAMA and HAMD and the levels of hs CRP and NT proBNP,improve HRV in patients with ACS accompanied by anxiety and depression.
Keywords：acute coronary syndromeanxietydepressionTongbi Shuxin granulehigh sensitivity C reactive proteinN terminal pro B type natriuretic peptideheart rate variability
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 124-128 )