Protective Effect of Yangxin Tongbi Decoction on Reperfusion Injury in Patients with Acute Myocardial Infarction after Thrombolysis Treatment
Wei Kun
Abstract：Objective To investigate the protective effect of Yangxin Tongbi decoction(YTD)on reperfusion injury in patients with a-cute myocardial infarction(AMI)after thrombolysis treatment.Methods Sixty four patients with AMI,from 2011 January to 2014 June in our hospital,were randomly divided into two groups:The control group(n=32)treated with conventional thrombolytic thera-py,and the treatment group(n=32)treated with conventional thrombolytic therapy plus YTD.Results After treatment of 2 h to 24 h, the level of high sensitivity C reactive protein (hs CRP)was increased.After treatment of 24 h,the level of hs CRP started to decline.The levels of hs CRP at each time point in treatment group were lower than those in control group(P<0.01).The levels of creatine kinase (CK),creatine kinase MB (CK MB)and troponin T (TnT) HS were increased after treatment of 2 h to 24 h,de-creased gradual y after treatment of 24 h.The levels of CK,CK MB and TnT HS at each time point in treatment group were lower than those in control group(P<0.05).After treatment of 1 day and 7 days,MIS in treatment group was less than that in control group(P<0.01).After treatment of 1 day and 7 days,left ventricular ejection fraction (LVEF)in treatment group was higher than that in control group(P<0.01).The rates of major adverse cardiac event (MACE)and reperfusion arrhythmia were lower than those in control group(P<0.05).Conclusion YTD can reduce reperfusion injury in patients with AMI after thrombolysis treatment, and improve left ventricular ejection function,to avoid the occurrence of adverse cardiovascular events.
Keywords：acute myocardial infarctionYangxin Tongbi decoctionthrombolysisreperfusion injury
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1927-1930 )