Intervention of Traditional Chinese Medicine on Signal Transduction Pathways in Heart Failure
Li Caihong
Wang Yonggang
Luo Wenping
Yu Yuanwang
Han Man
Zhong Wei
Qi Jing
Shang Junping
Abstract：Traditional Chinese medicine(TCM)has the curative effect on prevention and treatment of heart failure.The signaling path-ways in the occurrence and development of heart failure have transforming growth factor(TGF) beta/Smads signal pathway which inhibits the occurrence of myocardial fibrosis,PI 3k/AKT,JAK STAT and NF kB pathway inhibits inflammatory reaction and myo-cyte hypertrophy and delays ventricular remodeling.AMPK signal ing pathways regulates energy metabolism disorder and inhibits met-abolic remodeling occurs,CaN signal pathways which improves cardiac function,inhibits myocardial fibrosis,delays the occurrence and development of ventricular remodeling,and prevents and treats heart failure.Experiments show that Chinese medicine can regu-lat the expression of signaling pathways through multi links,multi channels,multi targets,and prevents and controls the origin and development of heart failure.
Keywords：heart failuretraditional Chinese medicinesignaling pathways
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1736-1739 )