Effects of Diankuang Mengxing Decoction on the Protein Expression of Matrix Metal oproteinase 9 in Rabbits with Atherosclerosis
Han Fengli
Yu Mingquan
Abstract：Objective To investigate the effects of Diankuang Mengxing decoction(DMD)on the protein expression of matrix metal o-proteinase 9 (MMP 9)in rabbits with atherosclerosis(AS).Methods Thiry two Japan big ear white rabbits were randomly di-vided into normal control group,model group,and DMD group.The atherosclerosis model was established with high fat diet.Al rab-bits were sacrificed at the end of the 12th week.Aortae was analyzed by histopathological examination.The protein expression of MMP 9 were detected by immunohistochemistry.Results There were severe pathological lesions in model group.DMD could di-minish greatly thickness of endomembrane.There were more protein expression of MMP 9 in model group.the protein expression of MMP 9 was reduced significantly in DKMXT group.Conclusion DMD can inhibit the expression of MMP 9,which may be contribu-ted to anti atherosclerosis in rabbits with atherosclerosis.
Keywords：atherosclerosisDiankuang Mengxing decoctionmatrix metal oproteinase 9big ear white rabbits
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1723-1725 )