Effects of Rosuvastatin on Vascular Remodeling and Vascular Reaction in Spontaneously Hypertension Rats
Zhang Zhulin
Ma Xiurui
Zhang Lizhen
Abstract：Objective To observe the effects of rosuvastatin on remodel and vascular reaction of aorta from spontaneously hyperten-sion rats (SHR).Methods SHR and Wister Kyoto (WKY)rats were randomly divided into:WKY control group,SHR treated with ro-suvastatin 6.25 mg/(kg· d),SHR treated with rosuvastatin 12.5 mg/(kg· d);rosuvastatin 25 mg/(kg· d),SHR control group.Therapy continued for 8 weeks.Tail systolic blood pressure was weekly measured before and after the study.At the end of this study,aorta was moved rapidly.A part of aorta was fixed with 4% paraformaldehyde to observe the vascular remodeling by HE stain.The vascular re-action of aorta was measured in vitro.Results Compared with WKY,the systolic blood pressure was higher,and vessel lumen diam-eter(L)decreased,while media thickness(M)and M/L increased in SHR.The contractions to phenylephrine(Phe),KCl in aorta were increased in SHR than in WKY.The relaxation to Ach decreased in SHR,but there was no difference of relaxation to SNP.Treatment with reosuvastatin induced a reduction in systolic blood pressure;increasing in L and decrease in M and M/L.Reosuvastatin reduced the contraction of aorta to Phe and KCl,increased the relaxation of aorta to Ach,but had no effect on the relaxation to SNP.Conclu-sion Reosuvastatin can retard the remodeling of aorta,improve the vascular reaction to different vasomotors,resume the balance of relaxation and contraction,protect endothelial function in SHR.
Keywords：spontaneously hypertensionrosuvastatinvascular remodelingvascular reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1608-1611 )