Effects of Donepezil Hydrochloride on the Recovery of Cognitive Function and Ability of Daily Living in Patients with Post stroke De-pression
Ye Haixia
Wang Yuanyuan
Tang Junfen
Chen Jie
Abstract：Objective To explore the efficacy of donepezil hydrochloride on the recovery of cognitive function and ability of daily living in patients with post stroke depression(PSD).Methods Eighty six patients with PSD from October 2011 to September 2013 were selected,and were randomly divided into two groups:The control group(n=43)treated with routine treatment plus functional reha-bilitation training,the treatment group(n=43)treated with donepezil hydrochloride and routine treatment plus functional rehabilitation training.Montreal Cognitive Assessment(MoCA),Fugl Meyer Motor Scale (FMA)and Barthel Index (BI)were used to evaluate the cognitive function,motor function and ability of daily living before training,at 8 weeks and 16 weeks after treatment.Results After 8 weeks of treatment,the scores of MoCA,FMA and BI in treatment group were higher than that in control group[(24.5± 1.9)vs(20.1± 1.4),(31.2± 8.3)vs (26.3± 8.1),(35.2± 7.5)vs (31.8± 6.3),P<0.05].After 16 weeks of treatment,the scores of MoCA,FMA and BI in treatment group were higher than that in control group[(28.2± 1.3)vs (22.5± 1.2),(34.1± 8.8)vs (27.1± 8.3),(36.2± 8.5)vs (31.6± 6.8),P<0.05].Conclusion Donepezil hydrochloride can improve cognitive function and enhance the ability of self care in patients with PSD.
Keywords：post stroke depressiondonepezil hydrochlorideMontreal Cognitive AssessmentFugl Meyer Motor Scale
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1489-1491 )