Influence of Sini Decoction on Blood Pressure and Baroreflex Sensitivity in Rats with Abdominal Aortic Coarctation
Wu Qiong
Liu Yongming
Gao Junjie
Shao Chunlin
Shen Zhijie
Chen Tiejun
Guo Wei
Wang Yingjie
Wang Xiaolong
Abstract：Objective To study the effects of Sini decoction(SND)on blood pressure and baroreflex sensitivity(BRS)in rats with ab-dominal aortic coarctation.Methods Fifty hypertension rats were established by abdominal aortic coarctation operation.After model-ing,rats were randomly divided into 5 groups:Sham operation group,SND group,SND plus perindopril group,perindopril group and model group.Rats were gavaged 4 weeks later.The sham operation group was the control group,perindopril as the positive control group.Caudal artery with continuous dynamic measurement instrument left forelimb blood pressure in rats.By cannulating into femoral artery,injecting phenylephrine into femoral artery,we observe the change of BRS,MAP,and HR. Results After modeling of 4 weeks,compared with the control group,the systolic blood pressure were significantly increased in each group(P<0.001).After drug intervention of 4 weeks,compared with the model group,the systolic blood pressure were significantly lower in SND group,SND plus perindopril group,perindopril group(P<0.001).The diastolic blood pressure was lower after modeling (P<0.05).After drug in-tervention,compared with model group,the BRS obviously increased in SND group,SND plus perindopril group,perindopril group(P<0.001).Conclusion SND can improve the blood pressure and increase the baroreflex sensitivity in rats with abdominal aortic coarctation.
Keywords：abdominal aortic coarctationSini decoctionbaroreflex sensitivityblood pressure
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1381-1384 )