Intervention Effect of Chaihu on Inflammation in Mice with Experimental Autoimmune Encephalomyelitis
Zhang Qi
Lin Chengren
Li Tao
Abstract：Objective To explored the effect of Chaihu for treatment of experimental autoimmune encephalomyelitis(EAE),and to pro-vide laboratory evidence for clinical application of Chaihu treating multiple sclerosis.Methods C57 mice were immunized by MOG 35 55 to establish EAE,the model of multiple sclerosis.Forty mice were divided into blank control group,EAE model group,predni-sone treatment group and Chaihu treatment group,which received oral administrations of different drugs after immunized 3 days.The mice behavior,checked daily and graded on clinical score were observed.It had been observed that cytokines levels of peripheral blood,relating to multiple sclerosis major factors,and inflammatory cel infiltration in spinal by HE staining after immunized 16 days. Results Compared with control group,the level of interleukin (IL) 17E,IL 17F,interferon(IFN)γwere increased while the level of IL 4 was decreased in EAE group(P<0.05).Compared with the EAE group,the level of IFN γand IL 17E significantly reduced in Chaihu group.The difference has statistic significance(P<0.05 or P<0.01).Conclusion Chaihu has theapeutic effect on the EAE mice by anti inflammation.
Keywords：experimental autoimmune encephalomyelitismultiple sclerosisChaihuprednisonecytokines
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 760-763 )