Effects of Pien Tze Huang on the Expression of BDNF and IL 6 Protein in Rats with Focal Cerebral Infarction
Meng Jia
Huang Xiyan
Li Qian
Zhu Lingqun
Abstract：Objective To observe the effect of Pien Tze Huang(PTH)on expression of brain derived neurotrophic factor (BDNF) and interleukin 6(IL 6)protein in rats with focal cerebral infarction model.Methods The middle cerebral artery occlusion (MCAO) was established by the modified Longa method.Sprague Dawley(SD)rats were randomly divided into sham operation group,model group,high,medium and low dose PTH group,Naodesheng(NDS)group and nimodipine group.Pathological damage were observed by HE staining.Results In the central area of infarction,the expression of BDNF and IL 6 protein in model group were significantly lower than that in sham operation group.The expression of BDNF and IL 6 protein in Pien Tze Huang group were higher than those in the model group.In the area around the infarction,expression of BDNF and IL 6 protein in model group were significantly higher than those in the sham operation group,BDNF protein expression in PTH group were higher than those in the model group while the expression of IL 6 protein was lower than that in model group.Compared with model group,high and medium dose PTH groups had significant improvement on pathologial changes in brain tissue.Conclusion PTH can up regulated expression of BDNF protein and down regulation expression of IL 6 protein after focal cerebral infarction,al eviate nerve function injury caused by cerebral ischemia.
Keywords：cerebral infarctionPien Tze Huangmiddle cerebral artery occlusionbrain derived neurotrophic factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 754-757 )