Effects of Qianyang Decoction on Left Ventricular Hypertrophy in Rats with Hypertension Induced by Abdominal Aorta Coarctation
Gao Junjie
Wu Qiong
Chen Tiejun
Wang Xiaolong
Chen Yani
Shen Zhijie
Xue Jingui
Zhang Chunling
Guo Wei
Abstract：Objective To study the effect and partial mechanism of Qiangyang decoction(QYD)on left ventricular hypertrophy(LVH) in rats with hypertension induced by abdominal aortic coarctation(AAC).Methods LVH model was established by AAC.Wistar rats were randomly divided into sham operation group and operation group.After hypertensive modeling,rats were randomly divided into model group,perindopril group and QYD group,there were ten rats in each group.After modeling,rats were gavaged for 8 weeks.LVH was determined by cardiac echocardiography,the blood pressure was determined by measuring left forelimb blood pressure with cau-dal artery continuous dynamic measurement instrument,myocardial col agen was observed by Sirius scarlet dye method,myocardial tissue type Ⅰ and type Ⅲ col agen fiber content was determined by immunohistochemistry.Results After 12 weeks of AAC,com-pared with the sham operation group,the systolic blood pressure,left ventricular posterior wal thickness (LVPWT)and interventric-ular septal thickness (IVST)were significantly increased in model group(P<0.001),while left ventricular end diastolic dimension (LVEDD)and left ventricular end systolic dimension (LVESD)were significantly decreased in(P<0.001).After intervention,com-pared with the model group,the systolic blood pressure,LVPWT and IVST of perindopril group and Qianyang decoction group are both significantly decreased(P<0.001),meanwhile,the LVEDD(P<0.001),and LVESD (P<0.05)were improved.Compared with the model group,myocardial tissue col agen fibrosis was less,type Ⅰ and type Ⅲ col agen expression was decreased.Conclusion QYD has effect against LVH in rats with hypertension induced by AAC,which is related with its antihypertension effect and inhibition of myocardial collagen fibrosis.
Keywords：hypertensionleft ventricular hypertrophyQianyang decoctionmyocardial col agen fibrosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 746-749 )