Regularity Research on Traditional Chinese Medicine Syndromes and Serum Adipokine Expression in Metabolic Syndrome

Xiao Tiegang; He Daotong; Xing Lianjun; Chen Junming; Ji Guang; Wang Bing

doi:10.3969/j.issn.16721349.2015.06.006

Abstract：Objective To investigate the relationship between traditional Chinese medicine(TCM)syndromes and serum adipokines in metabolic syndrome(MS).Methods Two hundreds and thirty five patients with MS were classified into four groups:Intermingled phlegm and blood stasis group,phlegm repressor groups,deficiency of both qi and yin group and yin deficiency and heat hyperactivity group.Serum adipokines were detected of MS,and then their TCM syndromes were counted by the frequency analysis.Results The relationship between serum fat factor and TCM syndromes showed that there was a higher level of the serum leptin(LEP),tumor nec-rosis factor α(TNF α),interleukin 6(IL 6),serum resistin and plasminogen activator inhibitor 1 (PAI 1)in both intermingled phlegm and blood stasis group and phlegm repressor group than that of deficiency of both qi and yin group,indicating a significantly statistical difference(P<0.05).The serum adiponectin(APN)level of intermingled phlegm and blood stasis group and phlegm re-pressor group were lower than that of deficiency of both qi and yin group,showing a significantly statistical differences(P<0.05). Compared with the other three groups,the retinol binding protein 4(RBP4)level was higher,there was a significantly statistical difference(P<0.05).TCM syndrome patterns of MS showed that the frequency of TCM symptoms tongue and pulse and pathogene-sis in MS patients had a certain regularity. The pathogenesis frequency was as fol ows phlegm repressor syndrome,intermingled phlegm and blood stasis syndrome,deficiency syndrome of both qi and yin,yin deficiency and heat hyperactivity syndrome in de-scending order.Conclusion Phlegm and blood stasis may be a key pathological aspects of adipokine secretion and metabolism and leading to MS.