Evaluation of Human Urinary Kal idinogenase for the Treatment of the Young Patients with Acute Cerebral Infarction According to Chinese Ischemic Stroke Subclassi cation
Hao Haiyan
Liu Fenghui
Wu Yonghui
Wang Yongjun
Abstract：Objective To evaluate the short term clinical efficacy and safty of human urinary kal i dinogenase in the treatment of of the young patients with acute cerebral infarction (ACI)according to Chinese Ischemic Stroke Subclassi cation(CISS).Methods Three hundreds and thirty two patients of 18 to 45 years old with ACI were divided randomly into two groups:Treatment group(n= 232) treated by 0.15 PNA of human urinary kal i dinogenase on the basis of basic treatment,and control group (n= 100)treated by basic treatment plus saline solution.The NIH Stroke Scale (NIHSS)scores were analyzed linking to CISS before and after 14 days of treat-ment.The treatment adverse reaction was abserved.Results The NIHSS scores of two groups after treatment were improved com-paraed with that before treatment(P<0.05).The scores in treatment group were significantly lower than that in control group(P<0.05).The NIHSS scores reduction level of the other 4 CISS types of stroke besides cardiogenic cerebral embolism in the treatment group exceeded that of the same stroke types in the control group (P<0.05).Serious adverse reaction were not found in both groups.Conclution Human urinary kal idinogenase can safrly improve the neurologic impairment in the young ACI patients with dif-ferent etiology.
Keywords：acute cerebral infarctionyouthhuman urinary kal idinogenaseChinese Ischemic Stroke Subclassi cation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 651-653 )