The Relationship between Endothelial Function and Blood Pressure in Elderly Hypertension
Li Xiuqiang
Abstract：Objective To study the relationship between endothelial function and blood pressure in elderly hypertension.Methods From September 2010 to May 2014,182 cases elderly hypertensive patients enrol ed into our hospital were divided into 3 groups ac-cording to blood pressure:62 cases ofmild hypertension,63 cases of moderate hypertension and 57 cases ofsevere hypertension.55 cases of healthy volunteers were col ected as the control.Results Compared with the control group,AngⅡ,endothelin 1(ET 1),vas-cular endothelial growth factor(VEGF)were increased (P<0.05),nitric oxide (NO)was decreased(P<0.05)in 3 elderly hyper-tensive groups.AngⅡ,ET 1 and VEGF were increased and NO was decreased with the blood pressure,respectively (P<0.05). Correlation analysis showed that AngⅡ,ET 1 and VEGF were positively correlated with blood pressure (P<0.05).NO was neg-atively correlated with blood pressure (P<0.05).Conclusion The hypertension and endothelial dysfunction are closely related. The endothelial dysfunction can be defined with Ang II,ET 1,NO and VEGF.
Keywords：elderly hypertensionendothelial functionAng Ⅱendothelin 1nitric oxideVascular end athelial gronth facfor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 625-627 )