Relationship between the Levels of Homocysteine and Mitogen activated Protein Kinases with Severity of Disease in Acute Coronary Syndrome
Jin Peng
Zhou Qi
Zhang Minli
Abstract：Objective To investigate the relationship between the levels of homocysteine(Hcy)and mitogen activated protein kinases (MAPK)and severity of disease in patients with acute coronary syndrome(ACS).Methods Two hundreds and eight patients with ACS were measured with levels of MAPK and Hcy by ELISA.The patients were divided into two groups:Group A [non homocys-teine (NHhcy)group,n= 106]and group B [homocysteine(Hhcy)group,n= 102].The coronary lesion count was assessed accord-ing to CAG.One month after the onset,cardiac ultrasound measurement applications was used to evaluate heart ejection fraction (LVEF).Results The proportion of single vessel lesion in group A was higher than that in group B(P<0.01).The proportion of double and three vessel lesion in group B was higher than that in group A(P<0.01).The concentration of MAPK in group B was higher than that in group A(P<0.05).The LVEF in group B was lower than that in group A(P<0.05).Conclusion Hcy can be as a predictor of disease severity in patients with ACS.MAPK can be as a supplement of prognosis evaluation in ACS patients by the appli-cation of Hcy.
Keywords：acute coronary syndromehomocysteinemitogen activated protein kinases
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 536-538 )